Read e-book online Animal Models of Ophthalmic Diseases PDF

By Chi-Chao Chan

ISBN-10: 331919433X

ISBN-13: 9783319194332

ISBN-10: 3319194348

ISBN-13: 9783319194349

This booklet describes experimental animal versions that mimic universal human ocular illnesses: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ sickness, and intraocular tumors. In conjunction, those types replicate the variety and application of instruments used to check human affliction. international professional clinicians talk about every one version in response to their medical event and the textual content is supported through a number of photographs and diagrams. In describing the main pertinent animal types of ophthalmic illnesses, this publication can be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and clinical students.

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2013). Further research using rats has shown that when hyperoxic conditions induce nuclear cataracts this is associated with mitochondrial DNA damage (Zhang et al. 2010). Some investigators have developed synthetic gels to replace the vitreous after vitrectomy and these studies have been primarily carried out in primates and rabbits (Maruoka et al. 2006; Swindle-Reilly et al. 2009). These studies were designed to help in re-attaching the retina after detachment and further studies are needed to determine if they can restore low oxygen tension at the surface of the lens.

Virchows Archiv A. Pathological Anatomy Histopathol 404(4):393–401 Obrosova IG, Chung SS, Kador PF (2010) Diabetic cataracts: mechanisms and management. Diabetes/Metabolism Res Rev 26(3):172–180. 1075 Okamura T, Miyoshi I, Takahashi K, Mototani Y, Ishigaki S, Kon Y, Kasai N (2003) Bilateral congenital cataracts result from a gain-of-function mutation in the gene for aquaporin-0 in mice. Genomics 81(4):361–368 Oriowo OM, Cullen AP, Chou BR, Sivak JG (2001) Action spectrum and recovery for in vitro UV-induced cataract using whole lenses.

Bowman Graw J, Jung M, Loster J, Klopp N, Soewarto D, Fella C, Fuchs H, Reis A, Wolf E, Balling R, Hrabe de Angelis M (1999) Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse. Genomics 62(1):67–73. 5974 Graw J, Klopp N, Illig T, Preising MN, Lorenz B (2006) Congenital cataract and macular hypoplasia in humans associated with a de novo mutation in CRYAA and compound heterozygous mutations in P. Graefes Arch Clin Exp Ophthalmol 244(8):912–919. 1007/ s00417-005-0234-x Graw J, Loster J, Soewarto D, Fuchs H, Meyer B, Reis A, Wolf E, Balling R, Hrabe de Angelis M (2001) Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene.

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Animal Models of Ophthalmic Diseases by Chi-Chao Chan

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