By Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein
Lately the significance of antigen-presenting cells and their effect at the eyes has been elucidated. we now have realized that almost each constitution of the attention harbors those cells, but they range of their actions and hence within the ways that they shield opposed to - or perform - ailments of the attention. Antigen-Presenting Cells and the attention summarizes present wisdom approximately ACPs mostly, and their function within the eye, particularly.
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Extra info for Antigen-presenting cells and the eye
The F4/80 molecule was cloned and sequenced by McKnight and colleagues who showed that the molecule exhibited significant amino acid sequence homology to the seven transmembrane domains of both the EGF and hormone receptor superfamilies (39). Despite such molecular advances, the function of the F4/80 molecule has remained elusive. Because F4/80 protein expression is required, it is speculated that F4/80 might enhance adherence of the tolerogenic APC to the other cells (lymphocytes and stromal cells) in the marginal zone.
Many years ago, epidermal LCs were shown to contain melanosomes when emigrating from healthy skin (38), and, more recently, it was shown that this transport of melanosomes decreases in the absence of TGF-β1-dependent LCs (39). Mucosal LCs have also been reported to capture apoptotic epithelial cells in the vagina and cervix (40). In the rat afferent lymph draining from the gut, a subpopulation of DCs contains apoptotic material from their sentinel tissue, which is brought into the mesenteric lymph node (41).
J Invest Dermatol 1996; 106:553–558. Jakob T, Udey MC. Regulation of E-cadherin-mediated adhesion in Langerhans celllike dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo. J Immunol 1998; 160:4067–4073. Price AA, Cumberbatch M, Kimber I, Ager A. Alpha 6 integrins are required for Langerhans cell migration from the epidermis. J Exp Med 1997; 186:1725–1735. Weiss JM, Sleeman J, Renkl AC, et al. An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function.
Antigen-presenting cells and the eye by Manfred Zierhut, Hans-Georg Rammensee, Wayne Streilein