Download e-book for iPad: Antitumor Steroids by R T Blickenstaff

By R T Blickenstaff

ISBN-10: 0121059529

ISBN-13: 9780121059521

ISBN-10: 0323139167

ISBN-13: 9780323139168

Antitumor Steroids examines using steroids, besides nonsteroidal antiestrogens and a few benzo[a]carbazoles, within the therapy of melanoma. It explains the mechanism through which steroids and their receptors interact to impact their physiological features as a rule and their antitumor job specifically. It additionally describes the systematic screening of antitumor compounds remoted from usual assets.
Organized into 9 chapters, this ebook starts with an outline of the position of steroids in melanoma therapy. It then discusses the estrogens, antiestrogens, and compounds (all containing an fragrant A-ring). the following chapters examine androgens, a few antiandrogens, derivatives according to C-19 steroids, progestins and corticoids, bile acids, and compounds with a side-chain carboxyl crew. The ebook explains the biogenesis and metabolism of androgens; the pharmacology of medroxyprogesterone acetate; the antitumor homes of certainly taking place corticosteroids; sterols and cucurbitacins; diet D and its metabolites; and cardenolides, bufadienolides, and withanolides. The publication concludes with a bankruptcy on bile acids, sapogenins and its analogs, and miscellaneous steroids.
This publication is a helpful source for natural and medicinal chemists biochemists, and pharmacologists attracted to using steroids in treating melanoma.

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Sella, R. G. Kilbourn, and K. Fitz (1991). Preliminary results of a phase II trial of estramustine (EMCYT) and vinblastine (VBL) for patients (pts) with hormone refractory prostate carcinoma (HRPC). 82nd Meeting of the American Association for Cancer Research, Houston, Texas, May 15-18. -E. Jonsson, C. Ingvar, M. Ferno, L. -M. Rudenstam (1988). Phase II study of estramustine phosphate (estracyt) in patients with metastatic melanoma. Eur. ]. Cancer Clin. Oncol. 24, 413-415. M. E. Stearns, D. P. Jenkins, and K.

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Gaeta, J. Saroff, and W. W. Scott (1977). A comparison of estramustine phosphate and streptozotocin in patients with advanced prostatic carcinoma who have had extensive irradiation. /. Urol. 118, 288-291. 21. R. Catane, J. Kaufman, A. Mittleman, and G. P. Murphy (1977). Combined therapy of advanced prostatic carcinoma with estramustine and presnimustine. /. Urol. 117, 332-334. 22. G. P. Murphy, R. P. Gibbons, D. E. Johnson, G. R. Prout, J. D. Schmidt, M. S. REFERENCES 23. 24. 25. 26. 27. 28. 29.

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Antitumor Steroids by R T Blickenstaff


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